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KMID : 0390320190290010039
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Chungbuk Medical Journal
2019 Volume.29 No. 1 p.39 ~ p.46
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Adverse events to antiepileptic drugs in children with epilepsy
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Seo Ah-Young
Kim Won-Seop
Kim Jon-Soo
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Abstract
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Purpose: Adverse events to antiepileptic drugs (AEDs) can significantly affect the life of children with epilepsy. We investigated the pattern of treatment-emergent adverse drug reactions (ADRs) in children diagnosed with epilepsy.
Methods: We conducted retrospective longitudinal follow-up study in single tertiary care teaching hospitals from January 2010 to December 2015. AED-associated ADRs, demographic and clinical characteristics, and causality, assessed by the World Health Organization-Uppsala Monitoring Center Scale, were recorded.
Results: A total of 772 children on AED therapy were screened, of which 50 children (6.5%) experienced 1 or more ADRs, and were enrolled in the study. Of the included children, 27 (54%) were boys, with a mean age of 9.9 years (range, 2 months - 17.7 years). The mean duration of epilepsy was 11.4±17.3 months, and 18% children had symptomatic epilepsy. More than two-third of children were on monotherapy, with oxcarbazepine (28%) and topiramate (22%) being the most common AEDs. Skin rash (30%) was the most common ADR, followed by somnolence (14%), dizziness (8%), cognitive decline (8%), violent behavior (8%), and others. Fourty ADRs were certain or probable, and 10 ADRs were possible. AEDs were withdrawn in 28 children and skin rash (43%) was most common ADRs.
Conclusions: Adverse events to AEDs, especially new-generation drugs, were very common among epileptic population in children. Careful monitoring and the systematic tracking of ADRs may lessen another burden among children receiving AEDs.
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KEYWORD
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Epilepsy, Children, Antiepileptic drug, Adverse drug reaction
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